Good physician-patient rapport and an anxiolytic, sedative, and amnesic premedication are necessary for comfortable, stress-free surgery under local anesthesia. Sufficient experience exists with the intramuscular and intravenous administration of the new benzodiazepine midazolam (Dormicum), while knowledge relating to its oral administration is still scant. Therefore, in a randomized double-blind study midazolam was investigated for oral premedication prior to local anesthesia: two dosages of midazolam were studied and compared with diazepam and placebo. One hour prior to ophthalmic surgery under local anesthesia, four randomized groups of 30 patients each, received a tablet of 7.5 or 15 mg midazolam, 10 mg diazepam, or a placebo. Following this medication, the anxiolytic, sedative, amnesic, and side-effects were determined at defined points of time during the day of surgery and the 1st postoperative day. Anxiolysis was determined using the "state-trait anxiety inventory (STAI)" of Spielberger et al.; sedation was assessed according to Pandit et al.; amnesia was determined by recall of picture cards which had been presented to the patients 50 min after premedication; and patients were asked about 13 side-effects typical of benzodiazepines in a standardized way. Anxiety increased little following the placebo; it decreased significantly following 10 mg diazepam and more markedly following 7.5 and 15 mg midazolam. Sedation increased little following the placebo; it increased more and similarly 50 min after the benzodiazepines; after 90 min the sedative effect was most marked for 15 mg midazolam. However, sedation was of shorter duration after midazolam than after diazepam.
It is a prescription drug and you have to strictly follow your doctor’s guidelines in using this medication. Take Dormicum® tablets immediately before going to sleep and swallow whole with fluid.
Read the patient information leaflet carefully before you start taking this medicine and each time you get a refill.
Your dosage will be based on your medical condition, response to treatment, weight, and other drugs you may be using.
If this medication is used continuously for a long time, It may cause withdrawal symptoms like sweating, vomiting, muscle cramps, seizures etc. If these symptoms occur stop using this medication or reduce the dose as advised by the doctor.
Dormicum 15 MG Dosages
The dosage and length of treatment are based on various factors like
Your medical condition
Other medicines you are using
Response to the treatment
Dormicum 15 MG is a potent sedative agent that requires slow administration and individualization of dosage.
Oral tablet doses for insomnia
Adults: 7.5 mg to 15 mg daily
Elderly: 7.5 mg daily
Premedication: 7.5 mg to 15 mg, should be given 30-60 minutes before the procedure
IV doses for conscious sedation
Adult: Initial dose is 2.5 mg five to ten minutes prior to operation. An additional dose of 1 mg may be given if required.
Adult more than 60 years: Initial dose is 1-1.5 mg five to ten minutes prior to operation. Further doses of 0.5-1 mg may be given. Maximum. 3.5 mg.
Induction Premed adult dose: 0.15-0.2 mg/kg IV.
Non-premed adult dose: 0.3-0.35 mg/kg body wt IV.
Maintenance 0.03-0.1 mg/kg/hr.
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Anaesthesia Premedication: 20-60 min before induction of anesthesia, the usual dose is 5 mg IV.
Doses for children: 0.08-0.2 mg/kg body wt IV.
In addition to the desired effects, Dormicum may cause some undesired side effects too. If these unwanted effects last for a long time or worsens, please talk to your doctor or pharmacist immediately.
Common side effects
- Shortness of breath
- Irregular heartbeat
Uncommon side effects
- Impaired balance
- Skin rash
If these side effects occur or worsen, immediately discuss with your doctor.
Remember that your doctor has prescribed Dormicum because he has judged that the benefit is greater than the risk of side effects. Many people using this medication do not have serious side effects.
This document does not list all possible side-effects of Dormicum.
If you experience side-effects or notice other side-effects not listed above, contact your doctor or pharmacist as early as possible. You may also report side effects to your local food and drug administration authority.
Dormicum 15 MG Precautions
Before taking this medication always consult with your doctor if you are allergic to it; or to other benzodiazepines (e.g., diazepam); or if you have any other allergies. This product may contain some inactive ingredients which can cause allergic reactions. Consult with your doctor.
This medication should not be used in certain diseases. Always talk to your doctor if you have: glaucoma (narrow-angle).
Before using this drug, please tell your doctor about your medical histories especially of Kidney problems, heart disease like congestive heart failure, glaucoma, chronic obstructive pulmonary disease-COPD etc.
After administration of this medication, continuous monitoring of cardiac and respiratory function is recommended until the patient is in stable condition.
Infants and children younger than 3 years are at increased risk of slower brain growth when using this medication for medical procedures.
This drug is not recommended during pregnancy and lactation.
Interactions of Dormicum 15 MG
Drug interactions may change how the drugs work or increase the risk of side effects when two or more drugs are taken together.
This document does not list all possible drug interactions. Please tell your doctor about all the medicines you are using. Do not stop, start or increase the dosage of any drugs without consulting your doctor.
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